Objective To analyze the situation and hot trend of venous thromboembolism（VTE） prevention abroad,in order to provide references for clinical guidelines and scientific research for nursing staff in China. Methods Core journal articles related to venous thromboembolism and prevention from Web of Science（WOS） from 2005 to 2020 were retrieved. CiteSpace software was used for the bibliometric and cluster analysis. Results The volume of papers issued in the research of VTE prevention is on the whole increasing trend. The research mainly focuses on drug prevention,physical prevention,complications observation,risk identification and VTE prevention in patients with different diseases. Among them,“precautionary duration” “intermittent pneumatic compression devices” “stroke”“anticoagulation” “clinical practice guidelines” and “oral anticoagulants” are the hot spots in the current research frontier. Conclusion The prevention of VTE is attracting the attention of scholars. It is recommended to promote the development of VTE prevention research in China and continuously improve the quality of clinical care by specifying the focus of VTE prevention research,broadening the range of VTE prevention populations,and formulating VTE preventive care guidelines.